MedSpace

PRIME Time in Rheumatoid Arthritis

Identification of preinflammatory mesenchymal, or PRIME, cells — that appeared in blood just before disease flares, by sequential RNA analysis before and during flares of RA

Roflumilast Cream for Chronic Plaque Psoriasis

Roflumilast cream contains a PDE-4 inhibitor

The mean baseline PASI scores were 7.7 in the roflumilast 0.3% group, 8.0 in the roflumilast 0.15% group, and 7.6 in the vehicle group; the mean change from baseline at week 6 was −50.0%, −49.0%, and −17.8%

Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus

Nemolizumab is a subcutaneously administered humanized monoclonal antibody against interleukin-31 receptor A

The median VAS score (0-to-100 scale when the baseline score is 100)

 for pruritus at baseline was 75. At week 16, the mean percent change in the VAS score was −42.8% in the nemolizumab group and −21.4% in the placebo group 

The mean percent change in the EASI (0-72) score was −45.9% with nemolizumab and −33.2% with placebo.

DLQI score of 4 or less was 40% in the nemolizumab group and 22% in the placebo group

DLQI; (range, 0 to 30, with higher scores indicating a greater effect on daily life)

Kawasaki like Syndrome – «pediatric inflammatory multisystem syndrome» or PIMS or «multisystem inflammatory syndrome in children» or MIS-C. Skin or mucous membranes were involved in up to 87% of the children

Es handelt sich um ein Symptom des Cowden Syndroms:

Genetic testing was performed and showed an inactivating mutation in the tumor-suppressor gene encoding phosphatase and tensin homologue (PTEN). The Cowden syndrome, an autosomal dominant PTEN hamartoma syndrome, is associated with an increased risk of breast, thyroid, endometrial, and other cancers. Oral mucosal papillomas are commonly associated skin lesions. Adapted from N Engl J Med 2020; 382:e29